COMPARE THE IMPACTION ON NEURO-INTRAOPERATIVE DURING THYROIDECTOMY BETWEEN SUGAMMADEX FOR REVERSAL OF ROCURONIUM AND SUCCINYLCHOLINE

Tuấn Anh Nguyễn, Đức Lam Nguyễn, Hữu Tú Nguyễn

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Abstract

The use of Neuro-intraoperative monitoring (NIM) during thyroidectomy reduce the rate of recurrent laryngeal nerve (RLN). However, patients must be in condition of non- paralyzed or complete reversal of muscle relaxation. A cross- sectional study was conducted from April to October 2020 to compare the effectiveness of sugammadex for reversal of neuromuscular blockade by low dose of rocuronium and depolarizing skeletal muscle relaxant Succinylcholine in thyroidectomy with NIM. Patients in S group got dose of 1mg/kg intubated succhinylcholine while patients in R group got dose of 0.5 mg/ Kg rocuronium for endotracheal tube placement and were revesal muscle relaxation with sugammadex. Research results showed that 100% patients achieved TOF >=0,9 after 3 minutes of sugamadex injection while 100 % patients in group S achieved TOF >=0,9 after 10 minutes. Patients in griup R and S both had preserved morphology and function of the recurrent laryngeal nerve. Group S had lower intubation quality than group R according to IDS score. The rate of coughing and intraoperative movement in group S was higher than that in group R. Both methods did not affect the NIM.

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References

1. Koçak S., Aydintug S. (2001). Surgeon's approach to the thyroid gland: Surgical anatomy and the importance of technique. World Journal of Surgery, 25, 968.
2. Nguyễn Toàn Thắng, Nguyễn Hữu Tú (2014). Thuốc giãn cơ, Gây mê hồi sức, Nhà xuất bản Y học, 43-44.
3. Chu K. S.,Tsai K. (2010). Influence of nondepolarizing muscle relaxants on intraoperative neuromonitoring during thyroid surgery.Journal of Otolaryngology-Head & Neck Surgery, 39, 397 – 402.
4. Margarita K., Maria G. (2016). Intraoperative Rocuronium Reversion by Low doses of Sugammadex in Thyroid Surgery with Monitoring of the recurrent laryngeal nerves. ARC Journal of Anesthesiology, 1, 19-28.
5. Nguyễn Hải Hà Trang, Nguyễn Hữu Tú (2019). Hiệu quả giải giãn cơ trong mổ bằng sugamadex để phẫu thuật cắt tuyến giáp có sử dụng máy phát hiện thần kinh. Tạp chí nghiên cứu y hoạc, 1281, 40-50.
6. Hoshi H., Kadoi Y., Kamiyama J. et al (2011). Use of rocuronium–sugammadex, an alternative to succinylcholine, as a muscle relaxant during electroconvulsive therapy. Journal of anesthesia, 25 (2), 286-290Lu I.C., Wu C.W. (2016). Reversal of rocuronium – induced neuromuscular blockade by sugammadex allows for optimization of neural monitoring of the recurrent laryngeal nerve. Laryngoscope,126,1014-9
7. Lê Văn Tiến, Nguyễn Hữu Tú (2019). Đánh giá tác dụng giãn cơ để đặt nội khí quản và thời gian thở lại sau khỏi mê bằng propofol kết hợp succhinylcholin ở các liều khác nhau. Luận văn thạc sĩ y học, trường Đại học Y Hà Nội
8. Kontoudi M., Gouliami M., Loizou C.et al. (2016). Intraoperative Rocuronium Reversion by Low Doses of Sugammadex, in Thyroid Surgery, with Monitoring of the Recurrent Laryngeal Nerves. ARC Journal of Anesthesiology. 1 (3), 19 - 28.