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Date Published: 07/08/2024
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DOI: https://doi.org/10.51298/vmj.v541i1.10625
Issue
Vol. 541 No. 1 (2024)
Section
Các bài báo
How to Cite
Lê, H. L. H., Trần, T. L., Tạ, V. T., Nguyễn, V. A., Phạm, H. A., & Nguyễn, H. V. (2024). LMP-1 EBV GENE DELETION MUTATIONS AND ASSOCIATED WITH EPSTEIN-BARR VIRUS STATUS IN NASOPHARYNGEAL CARCINOMA. Vietnam Medical Journal, 541(1). https://doi.org/10.51298/vmj.v541i1.10625

LMP-1 EBV GENE DELETION MUTATIONS AND ASSOCIATED WITH EPSTEIN-BARR VIRUS STATUS IN NASOPHARYNGEAL CARCINOMA

Hạ Long Hải Lê, Thị Lan Trần, Văn Thạo Tạ, Văn An Nguyễn, Hà Anh Phạm, Hoàng Việt Nguyễn

Main Article Content

Abstract

Nasopharyngeal carcinoma (NPC) is the most common type of head and neck cancer in Vietnam. Epstein Barr virus (EBV) plays important role to the development of NPC cancer cells via the Latent Membrane Protein 1 (LMP1). We conducted this study with the goal of determining the rate of deletion mutations in the 30bp LMP1 gene and its correlation with EBV concentrations in nasopharyngeal cancer tumors. Cross-sectional descriptive study design conducted on 140 biopsy tissue samples derived from nasopharyngeal cancer patients at Hanoi Medical University Hospital. LMP1 gene mutations were detected by PCR technique and EBV concentration in tumors were measured by Realtime PCR method. The results showed that 127/140 (90.7%) samples positive with the LMP1 gene and among them 75/127 (59.1%) samples carried to LMP-1 gene 30bp deletion mutation. Besides, the EBV concentration in the group with the mutation was higher than the group without the LMP1 gene deletion mutation, however p > 0.05. Our results showed that the LMP-1 deletion mutation of EBV is dominant in the population, increasing the ability of the virus to survive but does not significantly increase the EBV status in NPC tissues.

Article Details

Keywords

Nasopharyngeal cancer, LMP1 gene, Epstein-Barr Virus.

References

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