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Date Published: 07/08/2024
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DOI: https://doi.org/10.51298/vmj.v541i1.10636
Issue
Vol. 541 No. 1 (2024)
Section
Các bài báo
How to Cite
Bùi, K. C. (2024). FREQUENCY AND CORRELATION BETWEEN SINGLE NUCLEOTID POLYMOPHISM RS1042522 WITH SOME INDICES IN PATIENTS WITH TYPE 2 DIABETES. Vietnam Medical Journal, 541(1). https://doi.org/10.51298/vmj.v541i1.10636

FREQUENCY AND CORRELATION BETWEEN SINGLE NUCLEOTID POLYMOPHISM RS1042522 WITH SOME INDICES IN PATIENTS WITH TYPE 2 DIABETES

Khắc Cường Bùi

Main Article Content

Abstract

Introduction: Studies show the role of genetic factors in the risk of diabetes. Therefore, this study aimed to investigate the frequency of the single nucleotide polymorphism rs1042522 on the p53 gene and its association with the risk of type 2 diabetes. Subjects and methods: The study was conducted using a cross-sectional descriptive method, including 91 healthy people and 180 patients with type 2 diabetes. Allele-specific PCR method was used to analyze genotypes. Data were analyzed on GraphPrism 8.4. Results: The distribution rates of GG, GC and CC genotypes of rs1042522 in the study group were 24.72%, 50.55% and 24.72%, respectively. No differences were detected in blood glucose, HbA1c, Insulin and HOMA-IR indices between genotypes (p>0.05). Analyzing by recessive model, rs1042522 genotype was associated with the risk of type 2 diabetes with OR=2.058; 95% CI=1.096 - 3.822; p=0.0261. Conclusion: The proportions of GG, GC and CC genotypes of rs1042522 on p53 gene in the study group were 24.72%, 50.55% and 24.72%, respectively. The genotype of the rs1042522 polymorphism is associated with the risk of developing type 2 diabetes in a recessive model.

Article Details

Keywords

Diabetes, rs1042522, p53.

References

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