KHẢO SÁT TÍNH ĐA HÌNH GEN MATRIX METALLOPROTEINASE 9 Ở CÁC THAI PHỤ TIỀN SẢN GIẬT

Abstract

Objectives: To investigate the MMP-9 gene polymorphism (-1562 C>T) in healthy pregnant women and preeclamptic pregnant women at Hanoi Obstetrics and Gynecology Hospital. Subjects and methods: Two groups of pregnant women, including 120 physiologicallly pregnant women (control group) and 120 preeclamptic patients (patient group) from November 2021 to January 2023 at Hanoi Obstetrics and Gynecology Hospital.. Results: The CC, CT and TT genotype rates were 75%, 20,8%, 4,2%, respectively, in the preeclampsia group and 73,3%, 25%, 1,7% in the healthy pregnant women. There was no difference in the genotypes of the MMP-9 gene polymorphism (-1562 C>T) in the two groups of pregnant women with p > 0,05. The frequencies of C allele and T allele in preeclamptic pregnant women are 85,42% and 14,58%, respectively, in healthy pregnant women are 85,8% and 14,2%, respectively, the difference is not statistically significant with 95% confidence. No association between this gene polymorphysim and symptoms of preeclampsia has been found. Conclusion: There was no association between MMP-9 gene polymorphism (-1562 C>T) and preeclampsia in this study.