ĐÁNH GIÁ KẾT QUẢ THỤ TINH TRONG ỐNG NGHIỆM TRÊN BỆNH NHÂN ĐƯỢC TRƯỞNG THÀNH NANG NOÃN BẰNG GnRH AGONIST TẠI BỆNH VIỆN PHỤ SẢN TRUNG ƯƠNG NĂM 2019

Abstract

In recent years, GnRH agonist is know as the drug used to trigger follicular maturation instead of hCG in Antagonist regimen, combined with whole embryo freezing and frozen embryo transfer (FET) is a comprehensive solution to minimize ovarian hyperstimulation syndrome (OHSS) in in vitro fertilization. Objectives: 1) Describe some features of patients stimulate ovarian with GnRH antagonist regimen who were triggered for follicular maturation by GnRH agonist. 2) Evaluate the results of in vitro fertilization of these patients. Subjects and methods: The study was carried out by descriptive retrospective method, on 90 patients based on the combination of medical records and phone interviews. Results: For all patients did not need to hospitalize for ovarian hyperstimulation syndrome (OHSS), only ovarian hyperstimulation at mild level (13.33%) was recorded . The average number of oocytes obtained was 20.91 ± 7.13 oocytes, the number of matured oocytes accounted for 77.79%. Additionally, the average fertilization rate was 79.95 ± 20.01% and the average number of embryos was 13.27±6.21 embryos. The results of in vitro fertilization were well recorded, with the biochemical pregnancy rate reaching 55.20%, the clinical pregnancy rate reaching 44.03%, and the live birth rate reaching 34.33%. Conclusion: In vitro fertilization with an Antagonist regimen and oocyte maturation by GnRha gave good results in oocyte maturation rate, fertilization rate, clinical pregnancy rate, and live birth rate. The proportion of patients with ovarian hyperstimulation decreased significantly, especially there was no severe ovarian hyperstimulation. Keywords: GnRH agonist, ovarian hyperstimulation, in vitro fertilization.