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ASSESSMENT OF THE TOXICITIES OF CHOPE REGIMEN IN PATIENTS WITH PERIPHERAL T-CELL NON-HODGKIN LYMPHOMA
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Abstract
Objective: Evaluate the toxicity of the CHOPE regimen in patients with peripheral T-cell non-Hodgkin's lymphoma. Research subjects and methods: Descriptive study of a series of cases on 45 patients with peripheral T-cell non-Hodgkin lymphoma treated with the CHOPE regimen at K Hospital from May 2019 to May 2023. Results: 45 patients underwent 261 treatment cycles, 93.3% completed 6 cycles, 100% used the full dose. The most commen adverse effects on the hematopoietic system was anemia with 35.2%, leukopenia with 6 .1% (grade IV leukopenia with 1.9%) and thrombocytopenia with 1.9%. The most common non-hematopoietic toxicities was increased SGPT (20.9%), increased SGOT was 4.2%, peripheral neurotoxicity was 3.1%, nausea was 2.7%, vomiting was 1.9%, diarrhoea was 0.8%, mostly grade I-II; There were no cases of renal failure, mouth ulcers, constipation, and cardiovascular-related toxicity. Conclusion: CHOPE regimen was well tolerated.
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Keywords
Toxicity, CHOPE, etoposide and CHOP, peripheral T-cell non-Hodgkin lymphoma
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