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IMPACT OF CLINICAL DECISION SUPPORT SYSTEM IN PREVENTING DRUG-DRUG INTERACTIONS AMONG INPATIENTS IN GENERAL HOSPITAL OF AGRICULTURE
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Abstract
Objective: To analyze the impact of clinical decision support system in the management of drug-drug interactions in inpatients at General Hospital of Agriculture. Subjects and methods: interventional study design with before-after comparison. In the pre-intervention period, we retrospectively carried out all electronic prescriptions and medical records of inpatients treated from 01/05/2023 to 30/09/2023. In the post-intervention period, we prospectively performed monitoring reports on the drug-drug interaction warning system and pharmacist’s intervention from 01/11/2023 to 29/02/2024. Results: The proportion of patients exposed to drug-drug interactions (DDIs) decreased significantly from 7.00% in the pre-intervention period to 2.84% in the post-intervention period (p<0.05). There were no medical records with mandatory contraindicated DDIs in the post-intervention period. The frequency of medical records for contraindication DDIs with conditional decreased significantly from 0.36% to 0.04% and the frequency of medical records with major DDIs decreased significantly from 6.10% to 2.62%, in the pre-and post-intervention phases. The acceptance rate of physician for pharmacist's recommendations was 91.30%. Conclusion: The combining clinical decision support system with drug-drug interaction warnings and clinical pharmacist's intervention initially brings about effective DDIs management in hospital
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Keywords
: Drug-drug interactions, clinical decision support system
References
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