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Date Published: 08/08/2024
Abstract Views: 123
Views PDF: 70
DOI: https://doi.org/10.51298/vmj.v541i1.10684
Issue
Vol. 541 No. 1 (2024)
Section
Các bài báo
How to Cite
Nguyễn , T. T. T., Hoàng , N. A., Nguyễn , C. K., Nguyễn , Đình T., & Lê , P. T. (2024). STUDY ON ACUTE TOXICITY AND ANTICOAGULANT ACTIVITY OF TRIMERESURUS ALBOLABRIS VIPERIDAE VENOMS IN VIETNAM. Vietnam Medical Journal, 541(1). https://doi.org/10.51298/vmj.v541i1.10684 (Original work published August 7, 2024)

STUDY ON ACUTE TOXICITY AND ANTICOAGULANT ACTIVITY OF TRIMERESURUS ALBOLABRIS VIPERIDAE VENOMS IN VIETNAM

Thị Thùy Trang Nguyễn , Ngọc Anh Hoàng , Cửu Khoa Nguyễn , Đình Trung Nguyễn , Phúc Thịnh Lê

Main Article Content

Abstract

.Thromboembolism is one of the leading causes of death in the world. Foreign studies show that the green pit viper (Trimeresurus albolabris, family Viperidae) causes persistent blood clotting disorders, fibrin depletion, thrombocytopenia, ... Therefore, T. albolabris venom is a potential material in the study of anticoagulant effects, preventing thrombosis. In Vietnam, T. albolabris is distributed in the whole our country. However, studies on acute toxicity and pharmacological effects on them in Vietnam have not yet been studied. In this study, we evaluate the acute toxicity and anticoagulant effects of T. albolabris venom in Viet Nam. The results showed that the LD50 of T. albolabris venom in Swiss albino mice was 0.45 - 0.57 mg/kg by Miller-Tainter method and 0.47 mg/kg by the Behrens-Karber method. For subcutaneous injection, LD50 results are 4.42 - 5.54 mg/kg by the Miller-Tainter method and 4.47 mg/kg according to the Behrens-Karber method. T. albolabris venom at doses of 0.5 mg/kg and 0.25 mg/kg (subcutaneous injection) helps prolong blood clotting and bleeding time in test mice which compared to the control group.

Article Details

Keywords

green pit viper venoms, Trimeresurus albolabris, anticoagulant, bleeding time, coagulation time.

References

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