ĐÁNH GIÁ KẾT QUẢ BƯỚC ĐẦU TRIỂN KHAI GIÁM SÁT NỒNG ĐỘ THUỐC ĐỂ TỐI ƯU HÓA LIỀU VANCOMYCIN Ở NGƯỜI TRƯỞNG THÀNH TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2023 - 2024

Abstract

Objective: Determine the characteristics of vancomycin use, the rate of reaching vancomycin AUC/MIC target and evaluate the results of vancomycin dose adjustment to achieve target AUC/MIC of vancomycin in adult patients. methods: Prospective study with intervention to adjust vancomycin dose based on Bayesian estimated AUC in adults following to approved protocol at Can Tho University of Medicine and Pharmacy Hospital from August 2023 to May 2024. Dose adjustment intervention was performed during the study on each patient until the vancomycin dose met the AUC target of 400- 600mg.h/L. Results: The results of the intervention study on 45 patients showed that the rate of achieving the target AUC at the first dose was relatively low (42.2%) even though 75.6% of patients were prescribed an appropriate dosage regimen. After the first dose adjustment, the rate of achieving the AUC target increased significantly to 91.2% and 100% of patients reached the AUC target after 2 dose adjustments. Large variations in AUC during first measurement were observed along with variations in creatinine clearance in the patient population. Conclusion: TDM vancomycin helps improve the probability to achieve AUC/MIC targets in adult patients, and should be recommended to apply in clinical practice to improve the effectiveness and safety of vancomycin in treatment.