CARCINÔM TẾ BÀO GAN: VAI TRÒ CỦA ĐỘT BIẾN VÙNG PROMOTER CỦA GEN TERT VÀ MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG – CẬN LÂM SÀNG VÀ NGUY CƠ TÁI PHÁT SỚM

Abstract

Objectives: Mutations in the promoter region of telomerase reverse transcriptase (TERT) are common mutations in many types of cancer, including hepatocellular carcinoma (HCC). However, its role in early tumor recurrence remains unclear. Materials and Methods: Retrospective cohort study conducted at University Medical Center. TERT promoter mutation in 108 cases were detected by Sanger sequencing. Information on disease stage according to BCLC, test indicators such as HBsAg, Anti HCV, AST, ALT, AFP, GGT, WBC, PLT and time of tumor recurrence within 24 months after surgery were looked up from the medical records. Pathological characteristics such as tumor size, histological grade, vascular invasion, tumor necrosis and benign liver tissue condition were evaluated based on macroscopic descriptions and Hematoxyline - Eosin stained specimens. Results: Mutations in the promoter region of TERT occur in 46% of cases. High mutation rates are common in the Anti-HCV positive group and tend to be less common in the HBsAg positive group. TERT promoter region mutation status is not related to disease stage, AST, ALT, AFP indexes, tumor size, tumor histological features, cirrhosis. HCC cases with and without TERT promoter region mutations showed no difference in tumor recurrence-free survival. However, in very early HCC cases, mutations in the TERT promoter region are a negative factor in the risk of early recurrence. Conclusion: Our study shows that TERT promoter region mutations are common mutations in HCC in Vietnam and may have a role in the prognosis of early tumor recurrence in cases of very early stage HCC.