KHẢO SÁT TỶ LỆ BẤT THƯỜNG NỒNG ĐỘ FT4, TSH, KHÁNG THỂ KHÁNG THYROID PEROXIDASE Ở BỆNH NHÂN NÁM DA

Abstract

Objectives: To investigate of the serum levels of FT4, TSH, anti-thyroid peroxidase in patients with melasma. Methods: A cross-sectional study was conducted in HCMC hospital of dermato vernereology between 03/2023 and 08/2023. There were 52 melasma patients and 30 healthy people.  Results: The mean age was 45,8 ±. 9,5 years. The ratio of women and men were 96,1% and 3,9%, respectively. 61,5% of patients had a family history of melasma. 19,2% of patients used oral contraceptives. 76,9% of patients had a psychological stress. 69,2% of patients had intense sunlight exposure. 40,4% of patients were non-using sunscreen. 55,8% of patients used non-sunscreen methods to protect skin from the sun. 88,5% of patients had skin phototype 4. The median duration of the disease was 5years (between 1 and 20 years). The mean age of melasma onset was 40,1 ± 9,1 (between 21 and 63 years). The lesions were malar in 50%. 51,9% of patients had moderate level by MASI score. The ratio of abnormal serum levels of FT4, TSH, TPOAb in patient group was 18,2%, that was signigicantly higher than in control group (p = 0,024). In patient group, the serum levels of FT4, TSH, TPOAb were 1,13 ng/dl (± 0,19 ng/dl), 1,73 µIU/ml, and 13,42 UI/ml, respectively. Conclusions: This study suggests that there is a relationship between FT4, TSH, anti-thyroid peroxidase and melasma. However, to screen the relation of them, future research is needed.