SO SÁNH ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG BỆNH LÝ DỊ ỨNG KHOANG TRUNG TÂM (CCAD) VÀ VIÊM MŨI XOANG MẠN TÍNH TĂNG BẠCH CẦU ÁI TOAN ƯU THẾ

Abstract

Background: Central compartment atopic disease is a newly differentiated phenotype of chronic rhinosinusitis with a strong association with inhalant allergy. It was first described in 2017. In Vietnam, there has been no research concentrating on this disease. Objectives: To describe the clinical and paraclinical characteristics and laboratory results of central compartment atopic disease in the Vietnamese population and to compare them with eosinophilic chronic rhinosinusitis. Methods: This is a descriptive cross-sectional study including patients who have chronic rhinosinusitis, nasal polyps identified in nasal endoscopy and were indicated for functional endoscopic sinus surgery. These patients were classified as central compartment atopic disease (CCAD) or eosinophilic chronic rhinosinusitis (eCRS) by characteristics of their CT scan, nasal endoscopy and surgical confirmation of nasal polyps origin. A cut-off point for diagnosis of eCRS of 10 cells/HPF was used. Results: Fifty patients were collected with twenty-five patients in each group. CCAD group had a median age of 45,88 ± 12,69,  68% of them have allergic rhinitis and had a median SNOT-22 score of 31,68 ± 8,68, median Lund – Kennedy score of 7,84 ± 1,70, median Lund – Mackay score of 16,04 ± 4,18. In nasal endocsopy, 88% of CCAD patients had polyps originating from middle turbinate head, 76% from posterior superior nasal septum, 20% from superior turbinate. In CT scan images, 52% of them had black halo sign, 44% had medial-to-lateral sign, 12% had pansinusitis images. Conclusions: CCAD is a phenotype among a spectrum of chronic rhinosinusitis with a strong association with inhalant allergy and different characteristics from eCRS.