CÁC YẾU TỐ TIÊN LƯỢNG KẾT QUẢ ĐIỀU TRỊ CỦA UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ DI CĂN NÃO BẰNG PHƯƠNG PHÁP XẠ PHẪU GAMMA KNIFE

Abstract

Objective: Evaluate the prognostic factors for outcome of Gamma Knife radiosurgery for brain metastasis of non-small cell lung cancer. Material and Methods: We analyzed 79 patients with brain metastatic non-small cell lung cancer from July 2019 to July 2023. Selected patients have brain metastases from 1 to 5 tumors, size ≤ 3cm, KPS score ≥ 60. Patients were treated by stereotactic radiosurgery using Leksell Gamma Knife ICON unit (Elekta AB). We evaluated factors related to tumor control outcome and progression-free survival (PFS) in the brain. Results: In our study, the response rate at 3 months was 82,2%. Factors associated with response include: tumor size, dose, lesion morphology (p < 0,05). The percentage of PFS at 3 months was 88,6%; 6 months was 77,3%; 1 years was 74,9%. PFS was related to statistically significant with Karnofsky Performance status and number of metastatic lesions (p < 0,05). Conclusion: Tumor size, lesion type, dose are factors that have predictive value of tumor response, of which the Karnofsky score, number of metastatic sites with prognostics values of progression-free survival in the brain.