BƯỚC ĐẦU KHẢO SÁT TỶ LỆ VÀ ĐẶC ĐIỂM LÂM SÀNG BỆNH NHÂN UNG THƯ BIỂU MÔ TẾ BÀO GAI VÙNG KHẪU HẦU NHIỄM HPV TYPE NGUY CƠ CAO

Abstract

Background: HPV infection is not only a risk factor but also a prognostic factor in oropharyngeal cancer. Treatment response and survival outcomes in the patients with HPV-infected are often better than patients without HPV-infected. Objectives: Identifying high-risk Human papillomavirus (HR-HPV) prevalence and describe characteristics of oropharyngeal cancer patients with HPV- infected, treated at Can Oncology Hospital. Materials and methods: A cross-sectional descriptive study conducted at Can Tho Oncology Hospital from January 2023 to July 2023 on 30 patients with oropharyngeal cancer who had histology of squamous cell carcinoma (OPSCC). FFPE real-time PCR can be used to determine HPV status. Record demographic characteristics, stage and tumor location of oropharyngeal cancer patients with HPV-infected. Results: The median age was 58.73 ± 9.37. The ratio of men to women was 9:1. 56,7% of patients were HR-HPV positive results (17/30), of which 100% was HPV16 (30/30). Among 17 oropharyngeal cancer patients infected with HPV16, the majority of patients were in the age group 50-59 (43.3%); men (90%); rural areas (58.8%); the most common tumor location is the tonsils (58.8%), followed by the base of the tongue (35.3%) and soft palate (5.9%). There are 58.8% of hospitalized patients in stages III and IV and concurrent radiotherapy is the most common treatment method (47.1%). Conclusion: The rate of HR-HPV infection in OPSCC patients is high, most of which are HPV16. OPSCC patients with HPV16-infected are mainly men, diagnosed at a late stage and the tonsils