ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ U MÀNG NÃO ĐỘ CAO TẠI BỆNH VIỆN K

Abstract

Purpose: The study aimed to review the clinical, subclinical and treatment results of high-grade meningioma at Vietnam National Cancer Hospital. Subjects and methods: Descriptive study on 39 high-grade meningiomas patients who underwent surgery from July 2019 to December 2023. The patient received adjuvant treatment after surgery with radiosurgery or radiotherapy. We analyzed clinical, images of MRI and tumor control outcomes. Results: In our study, the average age was 56.31 ± 2.07 years old, the male/female ratio was 15/24; 80.6% of patients came to the hospital because of headaches; 82.1% of grade II meningiomas, 17.9% of grade III meningiomas; on MRI, 53.8% of tumors showed heterogeneous enhancement, 58.9% of tumor margins were irregular, 53.9% had peritumoral edema, average size 49.1± 15.28 (mm), 46.2% of tumors in the convexity, 33.3% tumors in the skull base, 12.8% tumors in the parasagittal and 7.7% tumor in the posterior fossa. Phẫu thuật Simpson I: 46,2%, Simpson II: 20,5%. Simpson I: 46,2%, Simpson II: 20,5%.  With an average follow-up time of 32.8 months (12 - 52 months), 8/32 patients with grade II meningiomas and 4/7 patients with grade III meningiomas had reccurrent. The control the tumor at 12 months was 94.9%, after 24 months was 82.4%, after 36 months was 63.6%. 2 patients with grade II meningiomas and 1 patient with grade III meningiomas died during follow-up. Conclusion: The extent of tumor resection may affect the outcome of treatment of highe grade meningioma (P=0.017). Adjuvant radiotherapy and postoperative radiosurgery for high-grade meningiomas are effective in local tumor control.