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Date Published: 07/09/2024
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DOI: https://doi.org/10.51298/vmj.v541i3.10865
Issue
Vol. 541 No. 3 (2024)
Section
Các bài báo
How to Cite
Lê, N. N. T., Trần, Đỗ H., & Trương, H. P. (2024). THE PRESENCE OF MECA AND MECI GENES AND THE LEVEL OF RESISTANCE TO THE ANTIBIOTIC METHICILLIN IN STAPHYLOCOCCUS AUREUS BACTERIA ISOLATED AT CAN THO CITY GENERAL HOSPITAL IN 2023-2024. Vietnam Medical Journal, 541(3). https://doi.org/10.51298/vmj.v541i3.10865

THE PRESENCE OF MECA AND MECI GENES AND THE LEVEL OF RESISTANCE TO THE ANTIBIOTIC METHICILLIN IN STAPHYLOCOCCUS AUREUS BACTERIA ISOLATED AT CAN THO CITY GENERAL HOSPITAL IN 2023-2024

Nguyễn Ngọc Thùy Lê, Đỗ Hùng Trần, Hoài Phong Trương

Main Article Content

Abstract

Background: Staphylococcus aureus is one of the leading causes of community and hospital-acquired infections. The mechanism of resistance to β-lactam antibiotics includes the ability of bacteria to produce β-lactamase and the presence of the mecA gene, in which the genetic resistance mechanism is considered more important. Objective: Determine the rate of mecA and mecI gene mutations and the resistance level of Staphylococcus aureus bacteria isolated at Can Tho City General Hospital in 2023-2024. Method: Cross-sectional descriptive study, data collected with a sample size of 81 S.aureus strains, from April 2023 to April 2024. Results: 81 S. aureus strains were isolated, of which 65 strains had a resistance phenotype and were PCR positive for mecA, 16 strains were positive for mecI. There is a relationship between bacterial strains carrying MecA or mecI genes and some patient characteristics such as age, gender and drug resistance of bacterial strains. Conclusions: Significant prevalence of the mec gene was found among MRSA isolated from clinical samples, potentially responsible for antibiotic resistance in MRSA.

Article Details

Keywords

Staphylococcus aureus, MRSA, mecA, mecI, antibiotic resistance.

References

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