BIỂU HIỆN DẤU ẤN TỀ BÀO GỐC UNG THƯ CK19 TRONG UNG THƯ BIỂU MÔ TUYẾN ĐẠI TRỰC TRÀNG

Abstract

Background: Colorectal cancer is a common type of cancer in the world and Vietnam, of which adenocarcinoma accounts for more than 95% of cases. CK19 is a specific cancer stem cell marker in some cancer tissues, especially adenocarcinoma of the digestive system, urinary system, genitourinary system,... even squamous carcinoma.  Objectives: To investigate the expression pattern of CK19 markers and determine the relationship with pathological characteristics in colorectal adenocarcinoma.  Materials and methods: Cross-sectional descriptive study; Analyze the general characteristics and pathological features of 102 cases of patients diagnosed with colorectal adenocarcinoma. Using immunohistochemical staining to investigate expression patterns and determine the relationship between CK19 marker expression patterns and pathological characteristics of colorectal cancer.  Results: There were 63 men and 39 women; The average age is 59.3±12.2 ys. There was only 01 negative, the remaining 101/102 showed positive expression for the CK19 marker. Among them, there are 50/102 (49%) strong positive cases; 39/102 (38.2%) cases were moderately positive; 12/102 (11.8%) cases were weakly positive. For general characteristics: there is a statistically significant difference and relationship between the staining intensity of CK19 with different ages, p <0.05; In addition, for the tumor location, the staining intensity also had a statistically significant difference, p < 0.05; There is a statistically significant difference and association between staining proportion and tumor location, p < 0.05; There is a statistically significant difference in CK19 marker expression between different ages, p<0.001. For macroscopic characteristics: there is a statistically significant difference in staining intensity and staining proportion with whether the tumor has polyps or not, p<0.05. For microscopic characteristics, the difference is not statistically significant. There was no relationship between CK19 marker expression and pathological features.  Conclusions: The CK19 marker showed positive expression at all levels in the studied cases, of which strong positive expression accounted for nearly 50% of cases; statistically significant differences in staining intensity and CK19 expression patterns between ages; about the staining intensity and staining proportion for the tumor location and whether the tumor has polyps or not. There is a relationship between staining intensity and age; between staining proportion and tumor location.