NỒNG ĐỘ HS-CRP HUYẾT THANH VÀ MỐI LIÊN QUAN VỚI ĐỘ NẶNG TRÊN BỆNH NHÂN VẢY NẾN

Abstract

Objective: To determine levels of serum hs-CRP of patients with psoriasis and its relationship to the severity of the disease. Methods: A case-control study was conducted on 90 patients with psoriasis at the Ho Chi Minh City Hospital of Dermato-Venereology in 2022 and 45 healthy people in the control group. Results: Median hs-CRP level in psoriatic patients was 9,9 mg/L (interquartile range 1,6 – 34,7 mg/L). Among them, median hs-CRP level in plaque psoriasis patients was 2,3 mg/L (interquartile range 1,1 – 8,9 mg/L), 46,5 mg/L (interquartile range 12,1 – 68,1 mg/L) in pustular psoriasis, 12,2 mg/L (interquartile range 1,6 – 17,8 mg/L) in psoriatic arthritis, 28,6 mg/L (interquartile range 6,4 – 40,2 mg/L) in erythrodermic psoriasis. The serum level of hs-CRP in the normal group was 1,2 (0,3 – 2,8) mg/L. The serum level of hs-CRP in the group of patients with psoriasis was significantly higher than in the control group (p < 0,001). The hs-CRP level was significantly correlated with the PASI score (r = 0,493; p < 0,001). Conclusion: There was an increase in hs-CRP level in patients with psoriasis in general, as well as in four subgroups of psoriasis including plaque psoriasis, pustular psoriasis, psoriatic arthritis, and erythrodermic psoriasis, and its change is related to PASI.