KHẢO SÁT NỒNG ĐỘ NGAL HUYẾT TƯƠNG, NƯỚC TIỂU VÀ GIÁ TRỊ TIÊN LƯỢNG Ở BỆNH NHÂN VIÊM TỤY CẤP CÓ TỔN THƯƠNG THẬN CẤP

Abstract

Background: Plasma and urine NGAL play a role in predicting acute kidney injury. Subjects and methods: Cross-sectional study of 219 patients with acute pancreatitis, including 51 patients with acute pancreatitis with acute kidney injury and 35 healthy people as healthy controls, from December 2021 to September 2023. Result: Plasma and urine NGAL concentrations of the acute pancreatitis group with acute kidney injury were higher than the group without acute kidney injury and were both greater than the healthy control group, the difference was statistically significant (p<0.01). The concentration of NGAL in plasma and urine at time T0 gradually increased according to the stages of acute kidney injury. Plasma and urine NGAL concentrations have little value in predicting acute kidney injury and predicting severe acute pancreatitis in patients with acute pancreatitis (AUC <0.7). Plasma NGAL concentration has a fairly good prognostic value in patients requiring continuous dialysis (AUC = 0.72; p < 0.05). Conclusion: Plasma and urine NGAL are valuable in predicting the occurrence of acute kidney injury, severity of acute pancreatitis and renal replacement therapy in patients with acute pancreatitis and acute kidney injury.