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CLINICAL AND SUBCLINICAL CHARACTERISTICS OF EOSINOPHILIC GASTROINTESTINAL DISORDERS BEYOND EOSINOPHILIC ESOPHAGITIS IN CHILDREN
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Abstract
Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis are a group of rare diseases characterized by the infiltration of eosinophils in the gastrointestinal tract. Aim: To describe the clinical and subclinical characteristics of children with eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis. Materials and methods: A retrospective and prospective study was conducted on 61 children diagnosed with eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis at the National Children's Hospital from July 2023 to March 2024. Results: The common symptoms were abdominal pain (75.4%), abnormal stool (49.2%) and weight loss (39.3%). Rate of gastrointestinal bleeding and perforation complications was 16.4% and 6.4%, respectively. Peripheral eosinophilia accounted for 50.8%. Prevalence of elevated level of IgE and calprotectin was 56.8% and 24.1%, respectively. 13% children had multi-site eosinophilic inflammation. Endoscopic and histologic findings were discordant in 8.6%. The most common endoscopy findings were erythema, nodularity, red spots and ulcerations.
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Keywords
Eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis, children, endoscopy, histology.
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