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Date Published: 12/09/2024
Abstract Views: 135
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DOI: https://doi.org/10.51298/vmj.v542i1.10949
Issue
Vol. 542 No. 1 (2024)
Section
Các bài báo
How to Cite
Lê , H. L. H., Tạ, V. T., Hồ, Ánh S., Nguyễn , V. A., Vũ, T. H., Trần, T. N., Pham, P. T., & Nguyễn , H. V. (2024). EPSTEIN-BARR VIRUS IN HODGKIN LYMPHOMA TUMORS BE REGULATED BY RS1049174 VARIANT OF NKG2D GENE. Vietnam Medical Journal, 542(1). https://doi.org/10.51298/vmj.v542i1.10949

EPSTEIN-BARR VIRUS IN HODGKIN LYMPHOMA TUMORS BE REGULATED BY RS1049174 VARIANT OF NKG2D GENE

Hạ Long Hải Lê , Văn Thạo Tạ, Ánh Sáng Hồ, Văn An Nguyễn , Thị Hà Vũ, Tín Nghĩa Trần, Phương Thảo Pham, Hoàng Việt Nguyễn

Main Article Content

Abstract

NKG2D is a receptor that plays a key role on immune cells’ surface which fighting viral infections. The rs1049174G/C variant on the NKG2D gene is of interest because of its role in regulating the activity of immune cells such as cytotoxic T cells and natural killer cells (NK). The study aimed to evaluate the rs1049174 variant on the NKG2D gene that regulates the amount of Epstein-Barr virus (EBV) in tumors derived from Hodgkin lymphoma (HL). The study was conducted on 77 HL tumors, resulting in genotype frequencies of GG (23.4%), GC (50.6%), CC (26.0%); the allele frequencies were 48.7% G and 51.3% C, respectively. Among a total of 77 HL cases, 19 cases (24.7%) were infected with EBV and the appearance of the C allele increased EBV concentration in HL tissue samples compared to the G allele (p = 0.01). The results of our study indicate the role of EBV and rs1049174 as potential targets for future immunotherapies for HL.

Article Details

Keywords

Hodgkin lymphoma, Epstein-Barr virus, NKG2D.

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