BIỂU HIỆN CỦA DẤU ẤN TẾ BÀO GỐC UNG THƯ (EPCAM) TRONG UNG THƯ BIỂU MÔ TUYẾN ĐẠI TRỰC TRÀNG

Abstract

Background: Epithelial Cell Adhesive Molecule (EPCAM) is a glycoprotein involved in the development and metastasis of colon adenocarcinoma. Objectives: we investigated the expression of EPCAM and its relationship with pathological characteristics of colorectal adenocarcinoma, particularly the pTNM stage.  Materials and methods: A cross-sectional descriptive study was conducted on 102 patients diagnosed with colon adenocarcinoma at 30-4 Hospital. Using immunohistochemical staining with EPCAM markers on paraffin blocks. Results: No case was negative. Expression according to Mokhtari’s evaluation method is as follows: 52.9% strong positive, 25.5% moderate to strong positive, 9.8% moderate positive, 11.8% weak positive; According to Spizzo’s evaluation method is as follows: 34.3% strong positive, 36.3% moderate positive, 29.4% weak positive. The difference in expression patterns of EPCAM with average ages is statistically significant (p<0.05) and the negative association between EPCAM expression patterns and average ages is statistically significant (p<0.001).  Conclusions: The expression pattern of EPCAM differs between ages and positive EPCAM expression decreases with increasing age.