SURVEYING THE CONCENTRATION OF TOTAL IRON BINDING CAPACITY IN PATIENTS WITH END-STAGE CHRONIC RENAL DISEASE
Main Article Content
Abstract
Objectives: To evaluate the serum total iron binding capacity (TIBC) and its relation with some clinical and subclinical indicators in patients with end-stage chronic renal disease (ESRD). Subjects and methods: A cross-sectional, descriptive study on 157 patients with end-stage chronic renal disease and 54 healthy controls matched for age and gender at 103 Military Hospital from January, 2022 to December, 2023. All of the above people had done measurement serum TIBC by ELISA method. Results: The concentration of plasma TIBC in the patient group 51,61 (21,69 – 73,03) (µmol/l) was lower than in the control group 70,39 (47,31 – 90,19) (µmol/l) with p < 0,001. The proportion of patients with decreased plasma TIBC was 28,7%. The rate of decreased TIBC in males was 36,1%, higher than in females at 20,3% with p < 0,05. TIBC levels were related to age, with the highest rate of decreased TIBC in patients aged ≥ 60 years, with p < 0,05. TIBC levels were positively correlated with protein levels (r = 0,213, p < 0,01). TIBC levels were positively correlated with red blood cell count (r = 0,192, p < 0,05), Hemoglobin (r = 0,229, p < 0,005), and Hematocrit (r = 0,215, p < 0,01). Conclusion: Plasma TIBC levels are decreased in patients with end-stage chronic renal disease. Plasma TIBC levels are related to gender and age. TIBC levels are positively correlated with Protein levels and red blood cell count
Article Details
Keywords
End stage renal disease, Total iron binding capacity.
References
2. Portolés, J., et al (2021), Anemia in Chronic Kidney Disease: From Pathophysiology and Current Treatments, to Future Agents. Front Med (Lausanne), 8: p. 642296.
3. KDIGO (2012), Clinical Practice Guideline for anemia in chronic kidney disease. Kidney International, 2: p. 279-335.
4. KDIGO (2012), Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney-international,.3: p. 5-8.
5. Li, J., et al (2015), Genome-wide admixture and association study of serum iron, ferritin, transferrin saturation and total iron binding capacity in African Americans. Hum Mol Genet, 24(2): p. 572-81.
6. Nguyễn Văn Hùng và cs (2018), Nghiên cứu nồng độ sắt, ferritin và khả năng gắn sắt toàn phần trong huyết tương ở bệnh nhân bệnh thận mạn tính chưa điều trị thay thế thận. Luận án Tiến sĩ y học, Học viện Quân y.
7. Goyal, H., et al (2017), Study of anemia in nondialysis dependent chronic kidney disease with special reference to serum hepcidin. Indian J Nephrol, 27(1): p. 44-50.
8. Phan Thế Cường và cs (2015), Đánh giá biến đổi nồng độ ferritin và độ bão hòa transferrin huyết thanh ở bệnh nhân suy thận mạn tính có chỉ định lọc máu chu kỳ. Tạp chí Y học Việt Nam, 433(2): p. 18-23.
9. Trần Thị Thuận (2010), Nghiên cứu sự thay đổi nồng độ sắt, ferritin, transferrin huyết thanh ở bệnh nhân suy thận mạn tính giai đoạn III - IV. Luận án Thạc sỹ y học, Học viện Quân y.
10. Ikeda-Taniguchi, M., et al (2022), Total iron binding capacity is a predictor for muscle loss in maintenance hemodialysis patients. Clin Exp Nephrol,26(6): p. 583-592.