SURVEYING THE CONCENTRATION OF TOTAL IRON BINDING CAPACITY IN PATIENTS WITH END-STAGE CHRONIC RENAL DISEASE

Văn Tuấn Bùi, Thành Chung Đặng, Việt Thắng Lê

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Abstract

Objectives: To evaluate the serum total iron binding capacity (TIBC) and its relation with some clinical and subclinical indicators in patients with end-stage chronic renal disease (ESRD). Subjects and methods: A cross-sectional, descriptive study on 157 patients with end-stage chronic renal disease and 54 healthy controls matched for age and gender at 103 Military Hospital from January, 2022 to December, 2023. All of the above people had done measurement serum TIBC by ELISA method. Results: The concentration of plasma TIBC in the patient group 51,61 (21,69 – 73,03) (µmol/l) was lower than in the control group 70,39 (47,31 – 90,19) (µmol/l) with p < 0,001. The proportion of patients with decreased plasma TIBC was 28,7%. The rate of decreased TIBC in males was 36,1%, higher than in females at 20,3% with p < 0,05. TIBC levels were related to age, with the highest rate of decreased TIBC in patients aged ≥ 60 years, with p < 0,05. TIBC levels were positively correlated with protein levels (r = 0,213, p < 0,01). TIBC levels were positively correlated with red blood cell count (r = 0,192, p < 0,05), Hemoglobin (r = 0,229, p < 0,005), and Hematocrit (r = 0,215, p < 0,01). Conclusion: Plasma TIBC levels are decreased in patients with end-stage chronic renal disease. Plasma TIBC levels are related to gender and age. TIBC levels are positively correlated with Protein levels and red blood cell count

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References

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