HIỆU QUẢ CỦA PHÁC ĐỒ SỬ DỤNG POLYETHYLENE GLYCOL 3350 TRONG ĐIỀU TRỊ TÁO BÓN CHỨC NĂNG Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI NGHỆ AN

Abstract

Functional constipation is considered the most common gastrointestinal disorder in children. Polyethylene glycol 3350 (PEG 3350) is recommended for the first-line treatment of functional constipation in children of all ages. Aim: To evaluate the efficacy of polyethylene glycol 3350 in the treatment of childhood functional constipation at Nghean Obstetric and Pediatric Hospital. Materials and methods: an interventional, prospective and no comparison study was conducted in 124 patients from 2 to 6 years old diagnosed with functional constipation according to Rome IV criteria at the Nghean Obstetric  and Pediatric Hospital from 01/07/2023 to 30/04/2024. Results: the mean age was 47.4 ± 15.7 months, boy/girl ratio was 1.1/1. Before treatment, prevalence of children with solid stools (type 2 in Bristol stool classification) was 47.6%, rates of straining and stool-retentive posturing were 75.8% and 68.5%, respectively. The percentage of children with type 4 and type 5 soft stools increased rapidly after 1, 2 and 3 months of treatment and was 78.4%, 85.4% and 93.5% respectively. The average number of bowel movements per week increased at 1, 2 and 3 months after treatment by 4.5, 6.0 and 6.4 times/week, respectively. The symptoms of straining, stool-retentive posturing, painful bowel movements and bloody stools improved markedly. The effectiveness of treatment with the regimen using PEG 3350 gradually increased from 78.4% after 1 month to 84.0% and 91.9% after 2 and 3 months. Side effects of PEG 3350 during treatment are very low. Conclusions: Polyethylene glycol 3350 has highly effective and safe in the treatment of functional constipation in children