ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ HÌNH ẢNH HRCT LỒNG NGỰC Ở BỆNH NHÂN BỆNH PHỔI KẼ DO MỘT SỐ BỆNH MÔ LIÊN KẾT

Abstract

Objective: To describe the clinical, subclinical characteristics and chest HRCT images in patients with interstitial lung disease related to some connective tissue diseases. Subjects and methods: A retrospective and prospective cross-sectional description of 52 CTD-ILD patients treated in National Lung Hospital from 3/2022 to 12/2023. Results: The disease is common in women (73.1%), average age of 56.7 ± 10.3 yrs, mainly over 50 yrs (78.8%). Common connective tissue diseases are scleroderma (42.3%) and idiopathic inflammatory myopathies (32,7%). Common respiratory symptoms are dyspnea (94.2%) and cough (84.6%). The common respiratory sign is crackles (90.4%). Common non-respiratory signs are skin thickening of the fingers (50.0%) and Raynaud's syndrome (44.2%). Inflammatory marker tests show average CRP concentration of 25.3 ± 37.5 mg/L and average first hour erythrocyte sedimentation rate  44,2 ± 31,0 mm/h. The average value of %FVC is 62.5 ± 17.2% pred.. The average value of %TLC is 62.8 ± 14.0% pred., with restrictive ventilatory  proportion of 83.9%. The main findings on HRCT are reticular opacities (88.5%) and ground glass opacities (88.5%), mainly basal predominant (96.2%) and peripheral predominant distribution (90.4%). The most common HRCT pattern is NSIP (55.8%), with 81.8% in scleroderma and 35.3% in idiopathic inflammatory myopathies. Conclusions: CTD-ILD is common in middle-aged women. Respiratory symptoms are non-specific while non-respiratory ones are diverse. Subclinical tests show inflammation and restrictive ventilatory. The pattern on chest computed tomography is mainly NSIP.