CLINICAL CHARACTERISTICS OF HOSPITALIZED PATIENTS WITH ACUTE HEART FAILURE

Đức Khánh Nguyễn , Phi Hùng Trương

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Abstract

Introduction: Patients hospitalized with acute heart failure (AHF) had very high mortality rate, significantly increasing the burden on families and the community. Clinical factors is crucial for devising aggressive treatment strategies aimed at reducing mortality and rehospitalization due to heart failure. Objective: To identify the clinical characteristics of patients hospitalized with acute heart failure. Subjects and Methods: This retrospective study selected records of patients diagnosed with acute heart failure or acute decompensation heart failure at Cho Ray Hospital, from January 2021 to August 2021. Clinical characteristics, laboratory results, and treatment medications were recorded from medical records. Results: A total of 478 records with acute heart failure or acute decompensation heart failure were recorded (mean age of 71 years, 57.7% men). Among these, 33.3% de-novo acute heart failure. Patients with renal dysfunction, chronic anemia, hypertension, diabetes mellitus, and dyslipidemia were 69%, 59.2%, 41.8%, 28.5%, and 21.1%, respectively. The most common symptoms were dyspnea (91.8%), fatigue (70.7%), edema (32.9%), pulmonary rales (52.9%), and third heart sound (24.7%). The heart rate was 98±16 bpm, and NYHA class III/IV was 76.6% (n=366). The mean hemoglobin concentration (Hb) was 120.6 ± 23.2 g/L, and the NT-proBNP level was 7480.47 ± 4856.2 pg/mL. Atrial fibrillation was 16.3%. The mean left ventricular ejection fraction was 42.7 ± 7.1, 42.1% of patients with HFrEF. The three most common causes of heart failure were coronary artery disease (57.7%), hypertensive heart disease (21.5%), and cardiomyopathy (14.4%). Common precipitating factors included non-adherence to medication (19.7%), infection (18.4%), acute coronary syndrome (18%), and uncontrolled hypertension (11.1%). Conclusion: Coronary artery disease was the most common cause of heart failure, and precipitating factors in AHF were non-adherence to medication, infection, and acute coronary syndrome. Patients hospitalized with acute heart failure had a high prevalence of comorbidities.

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References

Gheorghiade M, Zannad F, Sopko G, et al. Acute heart failure syndromes: current state and framework for future research. Circulation. Dec 20 2005; 112(25): 3958-68. doi:10.1161/ circulationaha.105.590091
2. Ambrosy AP, Fonarow GC, Butler J, et al. The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. Journal of the American College of Cardiology. Apr 1 2014; 63(12): 1123-1133. doi:10.1016/j.jacc. 2013.11.053
3. Crespo-Leiro MG, Anker SD, Maggioni AP, et al. European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions. European journal of heart failure. Jun 2016;18(6): 613-25. doi:10.1002/ejhf.566
4. Konstam MA, Gheorghiade M, Burnett JC, Jr., et al. Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. Jama. Mar 28 2007; 297(12): 1319-31. doi:10.1001/jama. 297.12.1319
5. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European heart journal. Jul 14 2016;37(27):2129-2200. doi:10. 1093/eurheartj/ehw128
6. Atherton JJ, Hayward CS, Wan Ahmad WA, et al. Patient characteristics from a regional multicenter database of acute decompensated heart failure in Asia Pacific (ADHERE International-Asia Pacific). J Card Fail. Jan 2012; 18(1): 82-8. doi:10.1016/j.cardfail.2011. 09.003
7. Yao HC, Li XY, Han QF, et al. Elevated serum soluble ST2 levels may predict the fatal outcomes in patients with chronic heart failure. International journal of cardiology. 2015;186:303-4. doi:10.1016/j.ijcard.2015.03.269
8. Gheorghiade M, Abraham WT, Albert NM, et al. Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure. Jama. Nov 8 2006; 296(18):2217-26. doi:10.1001/ jama.296.18.2217
9. Damasceno A, Mayosi BM, Sani M, et al. The causes, treatment, and outcome of acute heart failure in 1006 Africans from 9 countries. Arch Intern Med. Oct 8 2012;172(18):1386-94. doi:10.1001/archinternmed.2012.3310
10. Hoàng Văn Quang, Nguyễn Xuân Vinh. Đặc điểm lâm sàng, cận lâm sàng và kết quả điều trị suy tim mất bù cấp. Y học Việt Nam. 2016;Chuyên đề tháng 4:58-66.