TỈ LỆ LOÃNG XƯƠNG, NGUY CƠ GÃY XƯƠNG Ở NGƯỜI CAO TUỔI CÓ SỬ DỤNG THUỐC ỨC CHẾ BƠM PROTON

Abstract

Background: Bone fractures are the most serious consequence of osteoporosis, increasing treatment costs, reducing quality of life and increasing mortality. Objective: to survey the rate of osteoporosis and the risk of bone fractures in elderly people using proton pump inhibitors at the Geriatric Clinic and Musculoskeletal Clinic of Ho Chi Minh City University of Medicine and Pharmacy Hospital. Methods: Cross-sectional study was conducted on 220 patients aged 60 years and older, continuously using proton pump inhibitors (PPIs) for ≥ 4 weeks within 6 months visiting Ho Chi Minh City University of Medicine and Pharmacy Hospital. from December 2022 to June 2023. Results: the rate of osteoporosis in the elderly using proton pump inhibitors is 52.7%, of which women and men are respectively were 55.7% and 30.8% (p = 0.017). The high risk rate of bone fractures in elderly people using proton pump inhibitors is 53.2%, in which the rates for women and men are 52.1% and 61.5% (p = 0.363). Conclusion: Prolonged use of proton pump inhibitors in the elderly increases the risk of osteoporosis, decreased bone density and increased fractures.