ĐÁNH GIÁ MỐI LIÊN QUAN GIỮA CÁC MỨC ĐỘ CỦA CHỈ SỐ SPO2/FIO2 VÀ KẾT CỤC ĐIỀU TRỊ Ở BỆNH NHÂN ARDS

Abstract

Objective: The aim of this study was to evaluate whether level SpO₂/FiO₂ (S/F) ratio associated with outcomes in patients with ARDS. Methods: In this prospective observational study, we enrolled 90 patients with ARDS who were in Surgical intensive care unit (SICU) at Vietnam – Germany Friendship Hospital from March 2023 to September 2023. To determine the relationship between level of S/F and primary outcomes: 28 - day mortality, mechanical ventilation (days), ICU length of stay and the results of weaning ventilator included simple weaning, difficult weaning, prolonged weaning. Results: Overall 28-day mortality was 30% and there was no significant differences between patients with initial mild, moderate, and severe ARDS (p > 0,05). On day 3 reclassification, the hospital mortality rates were as follows: mild (14,9%); moderate (23,5%); and severe ARDS (37,5%) (p < 0,05). Patients with improving severity on day 3 could help to predict difficult weaning, prolonged weaning (p < 0,05) AUC = 0,738 (95% CI: 59,5% - 85,7%) and 0,646 (95% CI: 48,2% - 81%); respectively. Conclusions: S/F ratios after 48h of ARDS onset could help to divide patients into subgroups with greater separation in terms of mortality. Patients with improving severity on day 3 could help to predict difficult weaning, prolonged weaning.