ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN UNG THƯ SỐT HẠ BẠCH CẦU TRUNG TÍNH CÓ NHIỄM KHUẨN HUYẾT TẠI KHOA HỒI SỨC CẤP CỨU – BỆNH VIỆN K

Abstract

Objective: To evaluate the treatment outcomes for cancer patients with febrile neutropenia and sepsis. Subjects and methods: A cross-sectional study on 44 patients diagnosed with febrile neutropenia and sepsis from October 2019 to October 2020. Results: 47.7% of patients required a second-line antibiotic regimen after initial empirical antibiotic therapy. 65.9% of patients recovered, while 34.1% worsened and did not respond to treatment. Most patients needed a change in their antibiotic regimen when positive cultures were obtained; patients with negative cultures only required a single antibiotic regimen. Patients with lower neutrophil counts (grade III, IV) or higher SOFA scores (SOFA ≥ 9 points) had significantly higher mortality rates, whereas procalcitonin levels assessing infection status were not related to mortality rates. Conclusion: Antibiotic treatment regimens were adjusted appropriately based on the course of the disease and microbiological results. The mortality rate was as high as 34.1%. Patients with severe neutropenia (grade III, IV) had higher mortality rates compared to others. Patients with severe organ dysfunction (SOFA ≥ 9 points) also had higher mortality rates than the remaining group.