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CORRELATION BETWEEN SERUM ALPHA-FETOPROTEIN AND HISTOPATHOLOGICAL CHARACTERISTICS IN HBV-RELATED HEPATOCELLULAR CARCINOMA PATIENTS INDICATED FOR HEPATECTOMY
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Abstract
Objective: Determine the correlation between serum AFP and histopathological characteristics in HBV-related hepatocellular carcinoma (HCC) patients indicated for hepatectomy. Subjects and methods: A prospective, descriptive cross-sectional study of 58 patients with HCC undergoing hepatectomy at Military Hospital 103, Central Military Hospital 108, and K Hospital. Results: The median AFP concentration was 59.46 ng/mL, range 1.51 - 3000 ng/mL, with 34.5% of patients having AFP levels < 20 ng/mL. Most tumors have a moderate - differentiation according to WHO (rate 89.7%), ES grade III (rate 53.4%). The tumor structure is mostly trabecular, accounting for 53.4%. No correlation was found between AFP levels and histopathological features of the tumor in patients with HCC, p > 0.05. Conclusion: Most patients have elevated AFP levels, moderate – differentiation, ES grade III, and trabecular architecture tumor. No correlation was found between serum AFP and tumor histopathological characteristics.
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Keywords
Hepatocellular carcinoma, histopathology, alpha-fetoprotein, hepatectomy
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