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CORRELATION BETWEEN SERUM ALPHA-FETOPROTEIN AND HISTOPATHOLOGICAL CHARACTERISTICS IN HBV-RELATED HEPATOCELLULAR CARCINOMA PATIENTS INDICATED FOR HEPATECTOMY
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Abstract
Objective: Determine the correlation between serum AFP and histopathological characteristics in HBV-related hepatocellular carcinoma (HCC) patients indicated for hepatectomy. Subjects and methods: A prospective, descriptive cross-sectional study of 58 patients with HCC undergoing hepatectomy at Military Hospital 103, Central Military Hospital 108, and K Hospital. Results: The median AFP concentration was 59.46 ng/mL, range 1.51 - 3000 ng/mL, with 34.5% of patients having AFP levels < 20 ng/mL. Most tumors have a moderate - differentiation according to WHO (rate 89.7%), ES grade III (rate 53.4%). The tumor structure is mostly trabecular, accounting for 53.4%. No correlation was found between AFP levels and histopathological features of the tumor in patients with HCC, p > 0.05. Conclusion: Most patients have elevated AFP levels, moderate – differentiation, ES grade III, and trabecular architecture tumor. No correlation was found between serum AFP and tumor histopathological characteristics.
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Keywords
Hepatocellular carcinoma, histopathology, alpha-fetoprotein, hepatectomy
References
2. Anh PT, Phương TH: một số đặc điểm nồng độ afp trên bệnh nhân cắt gan do hcc tại bệnh viện k. Tạp chí Y học Việt Nam 2024, 535(1B).
3. Yan B, Wei JJ, Qian YM, Zhao XL, Zhang WW, Xu AM, Zhang SH: Expression and clinicopathologic significance of glypican 3 in hepatocellular carcinoma. Ann Diagn Pathol 2011, 15(3):162-169.
4. Phát HT, Thịnh NT, Vân PH, Duy NĐ, Thịnh HV, Diệp NBN, Duy NĐS, Minh HS, Thiện DH, Duy TK: Đặc điểm mô bệnh học của ung thư biểu mô tế bào gan ở bệnh nhân nhiễm vi rút viêm gan B. Journal of 108-Clinical Medicine and Phamarcy 2022.
5. Lauwers GY, Terris B, Balis UJ, Batts KP, Regimbeau J-M, Chang Y, Graeme-Cook F, Yamabe H, Ikai I, Cleary KR: Prognostic histologic indicators of curatively resected hepatocellular carcinomas: a multi-institutional analysis of 425 patients with definition of a histologic prognostic index. The American journal of surgical pathology 2002, 26(1):25-34.
6. Hu X, Chen R, Wei Q, Xu X: The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We? Int J Biol Sci 2022, 18(2):536-551.
7. Lalisang A, Jeo W, Moenadjat Y, Lalisang T: Correlation Between Serum Level of Alpha-Fetoprotein and Histological Differentiation Grade of Hepatocellular Carcinoma. Journal of Physics: Conference Series 2018, 1073:032056.
8. Si YQ, Wang XQ, Fan G, Wang CY, Zheng YW, Song X, Pan CC, Chu FL, Liu ZF, Lu BR et al: Value of AFP and PIVKA-II in diagnosis of HBV-related hepatocellular carcinoma and prediction of vascular invasion and tumor differentiation. Infect Agent Cancer 2020, 15(1):70.
9. Calderaro J, Couchy G, Imbeaud S, Amaddeo G, Letouzé E, Blanc JF, Laurent C, Hajji Y, Azoulay D, Bioulac-Sage P et al: Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. J Hepatol 2017, 67(4):727-738.
10. Yen YH, Kee KM, Li WF, Liu YW, Wang CC, Hu TH, Tsai MC, Lin CY: Stationary Trend in Elevated Serum Alpha-Fetoprotein Level in Hepatocellular Carcinoma Patients. Cancers (Basel) 2023, 15(4).