MỐI LIÊN QUAN GIỮA THỜI GIAN NHÂN ĐÔI CỦA THYROGLOBULIN VỚI TÁI PHÁT, DI CĂN Ở BỆNH NHÂN UNG THƯ TUYẾN GIÁP THỂ BIỆT HÓA SAU ĐIỀU TRỊ

Abstract

Objectives: The aim of this study was to evaluate the relationship between thyroglobulin double time and recurrence/metastatic lesions in patients with differentiated thyroid cancer after treatment. Methods: 151 patients underwent thyroidectomy and I-131 treatment in department of nuclear medicine, Hospital 108 from 2018 to 2/2024. After treatment, recurrence and metastases were detected in lesions that appear when disease-free for at least 6 months or in new lesions. At least two consecutive Tg measurements under the thyroid hormone replacement therapy (TSH ≤ 0,5 uIU/ml) to calculate TgDT before progression. We analyzed the relationship between clinical characteristics, histopathologic type, metastases and TgDT. Results: The median of TgDT is 29.3 months. The age group 55 and older has a lower TgDT than the group under 55. In looking for a relationship between histopathology and TgDT, the study seems to show that TgDT in the follicular cancer group is lower than the papillary group (p=0,048).  There is a statistically significant relationship between TgDT and distant metastasis (p<0,001). Subgroup analysis also showed that the bone metastasis group had a lower TgDT time than the lung metastasis and mediastinal metastasis groups (p<0.05). Conclusion: TgDT has a statistically significant association with recurrence and metastasis in patients with differentiated thyroid cancer after treatment.