TỔNG QUAN NGHIÊN CỨU SỬ DỤNG DẤU ẤN LIVER FATTY ACID BINDING PROTEIN ĐÁNH GIÁ SỚM TỔN THƯƠNG THẬN CẤP GIAI ĐOẠN 2013 – 2023

Abstract

Traditional diagnosis of kidney injury, especially acute kidney injury (AKI), relies on oliguria and increased serum creatinine levels, which are signs with low sensitivity and specificity and are delayed compared to the damage occurring in the kidney. Liver fatty acid binding protein (L-FABP) in urine is considered a useful biomarker for early detection of kidney injury. Objective: Application of L-FABP in early assessment of acute kidney injury. Research object: The research overview was conducted from studies and reports in the period 2013-2023 in the world and in Vietnam. Research methods: Online medical databases, documents, research works, theses, domestic and foreign conference reports were used to search for data, Zotero software 6.0 is used to manage and cite collected documents. Results: 20 studies and reports from around the world and Vietnam were selected for the study, including 18 articles using L-FABP to evaluate/predict/prognose AKI in diseases such as sepsis patients in intensive care unit (ICU), acute heart failure, decompensated heart failure, Diabetic Nephropathy (DN), Cirrhotic patients, Neonatal infections, postoperative prognosis, after organ transplant, after kidney transplant and there are 2 articles that are meta-analysis studies on the role of L-FABP. There was a positive correlation between L-FABP concentration in urine and the occurrence of AKI in the studied patients. Conclusion: AKI is a common clinical disease that leads to renal failure and a series of clinical syndromes. The increasing incidence of the disease is the leading cause of increased mortality worldwide. Early detection by L-FABP has a great importance for timely intervention and improved prognosis.