NGHIÊN CỨU SỰ BIẾN ĐỔI VÀ GIÁ TRỊ TIÊN LƯỢNG TỬ VONG SAU GHÉP GAN CỦA NỒNG ĐỘ LACTATE MÁU

Abstract

Objectives: To determine the changes in blood lactate concentration and to evaluate its prognostic value for 30-day mortality after liver transplantation at different time points: preoperative, intraoperative, and postoperative. Method: A retrospective, descriptive study of 97 patients who underwent liver transplantation from living donors at the 108 Military Central Hospital from January 2022 to February 2024. Results: The mean blood lactate concentration increased progressively from the preoperative period, peaking immediately postoperatively at 6,5 ± 3,1 mmol/L. Subsequently, the mean lactate concentration decreased over postoperative days 1 and 2, reaching its lowest value on postoperative day 3 at 1,6 ± 1,6 mmol/L. During the intraoperative and immediate postoperative periods, the lactate levels were significantly higher in the mortality group compared to the survival group (p<0,05). The lactate levels during these periods demonstrated prognostic capability for 30-day postoperative mortality with an AUC of 0,775 and 0,811, respectively (p<0,05). Conclusion: Blood lactate concentration progressively increases preoperatively and intraoperatively, peaking immediately postoperatively, followed by a gradual decrease postoperatively. Lactate levels during the intraoperative and immediate postoperative periods are valuable prognostic indicators of 30-day mortality post-liver transplantation.