KẾT QUẢ ĐIỀU TRỊ UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ ĐƯỢC XẠ TRỊ GIA TỐC TOÀN NÃO TẠI BỆNH VIỆN 19-8

Abstract

Objectives: To describe the clinical and paraclinical features of patients with non-small cell lung cancer (NSCLC) who underwent whole brain radiation therapy at 19-8 Hospital - Ministry of Public Security and to evaluate treatment outcomes in the studied patients. Patients and Methods: A retrospective study was conducted on 73 patients diagnosed with stage IV NSCLC with brain metastases, who received whole brain radiation therapy at the Oncology Center – 19-8 Hospital - Ministry of Public Security from January 2019 to December 2023. Results: Male patients accounted for 80.8%, with a median age of 65 years. Symptoms included headache (95.9%), nausea, vomiting (89%), cough (61.6%), chest pain (56.2%), fatigue, loss of appetite (71.2%), and weight loss (47.9%). A total of 71.2% of patients had 3 or more brain metastases. Brain metastases larger than 3 cm were observed in 45.2% of patients. Metastases in the cerebral hemisphere were noted in 58 cases, accounting for 79.5%. Histopathology were adenocarcinoma (80.8%). Whole brain radiation therapy for NSCLC with brain metastases showed an overall brain response rate of 58.9% and a disease control rate at the brain of 97.3%. The median progression-free survival (PFS) was 4 months (95%CI: 3.4-4.6). The 12-month PFS rate was 8%. The median overall survival (OS) was 7 months (95%CI: 6.2-7.5). The 12-month OS rate was 13.4%. Conclusion: Whole brain radiation therapy combined with systemic treatment in patients with stage IV NSCLC with brain metastases improved response rates and disease control in the brain, as well as survival outcomes.