HIỆU QUẢ GIẢM ĐAU CỦA PREGABALIN SAU PHẪU THUẬT NỘI SOI CẮT ĐẠI TRỰC TRÀNG

Abstract

Introduction: Postoperative pain has a complex mechanism including somatic factors in combination with nerves. The general trend in the treatment of acute postoperative pain is multimodal analgesia, in which the role of pregabalin neuroleptics is of increasing interest. Objective: to evaluate the analgesic effect of pregabalin on acute pain after laparoscopic colorectal surgery. Subjects and Methods: This prospective, randomized, non-blind, controlled study was performed on 70 patients undergoing elective laparoscopic colorectal surgery. Patients were randomly assigned to 2 groups: pregabalin and control. The pregabalin group received an oral dose of pregabalin 150 mg 2 hours before surgery. Postoperative analgesia includes patient-controlled intravenous paracetamol, nefopam and morphine. Morphine intake, pain scores at rest, during exercise, and adverse events during the first 24 hours after surgery were recorded. Results: After laparoscopic colectomy, the amount of morphine consumed in the pregabalin group was statistically significantly lower than in the control group (19.8 mg ± 2.6mg and 22.1 mg ± 4.5 mg, p = 0.01). There were no differences in pain scores at rest, during exercise and in adverse events between the 2 groups. Conclusion: The administration of pregabalin resulted in reduction in morphine consumption after laparoscopic colectomy. The administration of pregabalin did not improve pain scores at rest, on movement and did not increase adverse effects