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PREVALENCE OF HIGH-RISK HUMAN PAPILLOMAVIRUS GENOTYPES AMONG WOMEN WITH HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESIONS
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Abstract
Objectives: This study aims to assess the prevalence of high-risk Human papillomavirus (hrHPV) infection and the association of HPV 16 and 18 with high-grade squamous intraepithelial lesions (HSILs). Methods: The cross-sectional study included 106 patients who visited Hanoi Medical University Hospital from April 2022 to August 2023. All patients underwent hrHPV testing and cervical biopsies. The statistical analysis was performed using SPSS version 26.0 for Windows. Results: The prevalence of hrHPV infection among women with HSILs was 93.4%. Among these cases, 56.6% were infected with either HPV 16 or 18, with HPV 16 being the most prevalent at 47.2%. Age and hrHPV infection showed significant association with the severity of squamous epithelial damage (CIN 2, CIN 3). Conclusion: hrHPV infection was highly prevalent among women with HSILs at 93.4%. Age and infection with HPV 16 or 18 were associated with the severity of squamous epithelial damage (CIN 2, CIN 3).
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Keywords
Human papillomavirus, high-grade squamous intraepithelial lesion, HSIL, CIN.
References
2. Ojha PS, Maste MM, Tubachi S, et al (2022). Human papillomavirus and cervical cancer: an insight highlighting pathogenesis and targeting strategies. Virusdisease. 2022 Jun;33(2):132-154.
3. Clifford G, Franceschi S, Diaz M, et al (2006). Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine. 2006;24 Suppl 3:S3/26-S3/34. doi:10.1016/j.vaccine.2006.05.026.
4. Schiffman M, Castle PE, Jeronimo J, et al (2007). Human papillomavirus and cervical cancer. Lancet. 2007. 370 (9590):890-907.
5. Karube A, Saito F, Waga M, et al (2021). Progression of cervical intraepithelial neoplasia grade 2 lesions among Japanese women harboring different genotype categories of high-risk human papillomaviruses. J Rural Med. 2021;16(2):91-97. doi:10.2185/jrm.2020-038.
6. Lê Quang Vinh, Đàm Thị Quỳnh Liên, Lưu Thị Hồng và CS (2017). Tình hình nhiễm HPV nguy cơ cao ở những phụ nữ có tổn thương tân sản nội biểu mô và ung thư cổ tử cung. Tạp chí Phụ sản 15(02), 125-29.
7. Xiao M, Xu Q, Li H, et al (2016). Prevalence of Human Papillomavirus Genotypes Among Women With High-Grade Cervical Lesions in Beijing, China. Medicine (Baltimore). 2016;95(3):e2555. doi:10.1097/MD.0000000000002555.
8. Kamolratanakul S, Pitisuttithum P (2021). Human Papillomavirus Vaccine Efficacy and Effectiveness against Cancer. Vaccines (Basel). 2021;9(12):1413. Published 2021 Nov 30. doi:10.3390/vaccines9121413.
9. National Cancer Institute (2020). ACS’s Updated Cervical Cancer Screening Guidelines Explained.