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Date Published: 14/10/2024
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DOI: https://doi.org/10.51298/vmj.v543i1.11309
Issue
Vol. 543 No. 1 (2024)
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How to Cite
Trần, L. T. C., Dương, P. A., & Trần, P. H. Y. (2024). IMPROVED SOLUBILITY OF GLICLAZIDE BY FORMATION THE MULTICOMPONENT CRYSTALS WITH TROMETHAMINE. Vietnam Medical Journal, 543(1). https://doi.org/10.51298/vmj.v543i1.11309

IMPROVED SOLUBILITY OF GLICLAZIDE BY FORMATION THE MULTICOMPONENT CRYSTALS WITH TROMETHAMINE

Lê Tuyết Châu Trần, Phước An Dương, Phi Hoàng Yến Trần

Main Article Content

Abstract

Gliclazide is a second generation, sulfonylurea oral hypoglycemic agent, and is used in the treatment of type 2 diabetes. Gliclazide is a Biopharmaceutical Classification System (BCS) class II drug (low solubility and high permeability) which is likely to be dissolution rate limited. The multicomponent crystals between gliclazide and tromethamine (MCGLI-TRO) was prepared by using the solvent evaporation method. The solubility of gliclazide in MC was significantly increased 243 times than the raw material. The results of XRD, DSC and FT-IR measurements also confirmed the formation of crystal between gliclazide and tromethamine.

Article Details

Keywords

Gliclazide, Tromethamine, multicomponent crystals, solvent evaporation method, sulfonylurea.

References

. Palmer KJ, et al. Gliclazid. An update of its pharmacological properties and therapeutic efficacy in non-insulin-dependent diabetes mellitus. Drugs. 1993;46(1):92-125.
2. Delrat P, et al. Complete bioavailability and lack of food‐effect on pharmacokinetics of gliclazid 30 mg modified release in healthy volunteers. Biopharmaceutics & drug disposition. 2002; 23(4):151-157.
3. Putra OD, et al. Drug–drug multicomponent crystals as an effective technique to overcome weaknesses in parent drugs. Crystal growth & design. 2016;16(7):3577-3581.
4. Nugrahani I, et al. Zwitterionic cocrystal of diclofenac and l-proline: structure determination, solubility, kinetics of cocrystallization, and stability study. European Journal of Pharmaceutical Sciences. 2018;117:168-176.
5. Zaini E, et al. Multicomponent Crystal of mefenamic acid and N-methyl-D-glucamine: crystal structures and dissolution study. Journal of pharmaceutical sciences. 2019;108(7):2341-2348.
6. Neurohr Cm. Élaboration de cocristaux pharmaceutiques par procédés assistés au CO2. 2015