KHẢO SÁT VÀ PHÁC THẢO DANH MỤC TƯƠNG TÁC ĐIỀU TRỊ CẦN CHÚ Ý TRONG THỰC HÀNH LÂM SÀNG TẠI BỆNH VIỆN ĐA KHOA ĐỒNG NAI

Abstract

Background: Drug interactions are a common problem in clinical practice and are one of the causes of adverse drug reactions. Objective: This study was thus conducted to survey on patient background characteristics and drug status in prescriptions, identify factors affecting drug interactions in clinical practice at Dong Nai general hospital. Study population and methods: A descriptive cross – sectional study was conducted on 500 prescriptions of outpatient treatment standards from November 1^st 2019 to March 30^th 2020 at Dong Nai General Hospital. Data collected and analyzed on prescriptions included patient characteristics, number of prescriptions, pathological characteristics, drug interaction characteristics, and factors affecting drug interactions. Results: The rate of prescriptions with clinically significant interactions accounts for 44.60%. The number of prescriptions with 1 interaction accounts for 14%, 2 interactions account for 9.80%, and 3 interactions account for 3.60%. People aged 65 years and older are 2.2 times more likely to experience interactions than patients under 65 years old. An increase in the number of diseases increases the risk of drug interactions occurring by 2 times. Patients with diabetes are 8.9 times more likely to experience interactions than other diseases, followed by lipid disorders (5.4 times), and coronary heart disease (5.4 times), hypertension (3.4 times), digestive system diseases (3.3 times), liver diseases (3.1 times). In particular, the number of diseases also increases the risk of serious interactions by 1.5 times. Conclusion: Drug interactions occur relatively high when patients use multiple drugs simultaneously. Therefore, it is necessary to develop a list of drugs with notable and high frequency interactions, and strengthen the role and consulting function of clinical pharmacists for patients who use multiple drugs or drugs. coordinate appropriately, limit interactions and achieve high treatment effectiveness.