ĐIỀU CHẾ HỆ NANO SILICA CHỨA IBUPROFEN CÓ HOẠT TÍNH KHÁNG VIÊM BẰNG PHƯƠNG PHÁP NHIỆT ẨM

Abstract

Mesoporous silica nanoparticles (MSNs) have shown applications in a wide range of clinical applications including drug delivery, gene-transfection, and multimodal imaging due to their unique surface properties. There are some techniques for fabricating MSNs including hydrothermal method, sol – gel method, Stöber method... Nanoparticle-mediated drug delivery systems have been used in anti-inflammatory therapies. Efficient delivery of anti-inflammatory drugs can reduce medical dosage and improve therapeutic effect. This study was investigated on some reaction conditions such as the CTAB/TEOS molar ratio, the NaOH/TEOS molar ratio, temperature of the reaction, temperature of the reaction. MSNs were prepared by the hydrothermal method. The results revealed the successful preparation of MSNs with mean size from 193 nm to 734.35 nm, negatively charge of −37 mV, surface area of 941 m²/g. The MSNs-loaded ibuprofen had 14% loading efficacy, and 32% entrapment efficiency.