ĐẶC ĐIỂM CẬN LÂM SÀNG – MÔ BỆNH HỌC CỦA CARCINÔM TẾ BÀO GAN LOẠI VIÊM GAN THOÁI HÓA MỠ

Abstract

Objective: Determine the prevalence of Steatohepatitic HCC subtype in Vietnamese patients and the role of this subtype in the prognosis of early recurrence. Materials and Methods: From 108 patients undergoing hepatectomy due to HCC at the University Medical Center Ho Chi Minh City in 2018, cases diagnosed as SH-HCC and C-HCC were selected. We compared the clinical characteristics, histopathological characteristics of tumor liver tissue and background liver tissue, CK19 expression, and TERT promoter mutation status and compared the early recurrence rate between the SH-HCC and C-HCC groups. Results: SH-HCC accounts for 15.7% of all HCC subtypes. The SH-HCC subtype tends to have less tumor necrosis and microscopic vascular invasion, as well as the underlying liver tissue has a higher degree of fatty degeneration than the C-HCC group. There is no difference in the rate of early tumor recurrence between the 2 groups. However, SH-HCC tumors with microscopic vascular invasion will have a significantly higher early recurrence rate than the C-HCC group. Conclusion: SH-HCC is the second most common subtype among all HCC cases with a rate of 15.7%. The risk of early recurrence between SH–HCC and C–HCC subtypes is not different.