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THE EFFECTIVENESS OF ENDOCRINE COMBINED WITH CDK4/6 INHIBITORS IN PATIENTS WITH HORMONE RECEPTOR-POSITIVE, HER2-NEGATIVE STAGE IV DE NOVO BREAST CANCER
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Abstract
Objectives: To evaluate the effectiveness of endocrine combined with CDK4/6 inhibitors in patients with hormone receptor-positive, HER2-negative de novo breast cancer (stage IV). Patients and methods: A retrospective and prospective descriptive study on 48 patients diagnosed with hormone receptor-positive, HER2-negative de novo breast cancer at K Hospital from January 2020 to February 2024. Result: The mean age was 56,0 years. The most common metastatic sites were bone, lympho node, lung and liver, respectively, accounting for 70,8%, 41,7%, 35,4% and 25%. The overall response rate of the regimen was 77,1%. The complete response rate was 2,1%, the partial response rate was 75% and 10,4% of the patients were stable. The clinical benefit rate was 87,5%. The median progression-free survival was 26 months. Conclusion: Endocrine combined with CDK4/6 inhibitors is effective inachieving high response rates and progression-free survival for patients with hormone receptor-positive, HER2-negative de novo breast cancer. This regimens should be more widely used in clinical practice.
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Keywords
de novo - metastatic breast cancer, hormone receptor-positive, HER2-negative, CDK4/6.
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