SO SÁNH TÁC DỤNG CẦM NÔN GIỮA ONDANSETRON VÀ DOMPERIDONE TRONG ĐIỀU TRỊ VIÊM DẠ DÀY RUỘT CẤP Ở TRẺ EM CÓ NÔN

Abstract

Introduction: Vomiting is the most common clinical presentation of acute gastroenteritis (AGE) and can limit the effectiveness of oral rehydration therapy. Antiemetics can reduce vomiting and facilitate oral rehydration therapy. Objective:The purpose of this study is to compare the antiemetic effects of ondansetron (O) and domperidone (D) in children with acute gastroenteritis (AGE) associated with vomiting. Methods: Randomized controlled open-label trial. One group of children received orally a single dose of O syrup (0.15 mg/kg), while the other received orally a single dose of D suspension (0.5 mg/kg). Results: After 4 hours, more patients had ceased vomiting in the O group (81.8%) than in the D (71.6%) (p<0.05). After 24 hours, 98.4% of the O group had stopped vomiting, compared to 88.3% in the D group (p<0.05). There was no statistically significant difference between the 2 groups in the proportion of children receiving IV rehydration (6.6% vs. 15.1; p>0.05), ORS intake at 24 hours (500 [IQR 300-500] vs. 500 [IQR 300-500] ml; p>0.05), the duration of diarrhea (70.4±23.1 vs. 69.7± 24.5 hours; p>0.05) and the duration of hospitalization (3.8±1.4 vs. 3.7±1.6; p>0.05). Conclusions: Ondansetron has a better antiemetic effect than domperidone and may lead to a reduction in IV rehydration for children with AGE associated with vomiting.