NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG VÀ NỒNG ĐỘ PROLACTIN HUYẾT TƯƠNG Ở BỆNH NHÂN TRẦM CẢM NỮ

Abstract

Objectives: Evaluation of clinical symptoms and changes in plasma prolactin levels in female depressed patients. Subject and methods: Uncontrolled clinical intervention study, longitudinal study, comparing results before and after treatment in 43 female depressed patients treated inpatients at the Department of Psychiatry, Military Hospital 103 from January 2024 to May 2024. Results: Of the 43 patients studied, 93.02% of patients with disease onset were from 18 years old; 46.51% had disease duration of less than 1 year. 100% of patients had symptoms: decreased mood and loss of interest or pleasure, diminished appetite, bleak and pessimistic; psychomotor retardation accounted for 97.67%, suicidal thoughts and behavior were found in 72.09% of patients. Plasma prolactin concentration decreased when depression stabilized, pre-treatment concentration was 1697.5 ± 1026.3 µU/mL and after treatment was 592.2 ± 543.9 µU/mL (p<0, 05). Conclusion: Plasma prolactin concentrations are elevated in female depressed patients and return to normal values ​​when depression is stabilized.