KẾT QUẢ GHÉP GAN TỪ NGƯỜI HIẾN CHẾT NÃO TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC

Abstract

Objective: evaluating the clinical, laboratory characteristics of recipients, the short – term and long – term outcome of brain - dead donor liver transplantation carried out in VietDuc university hospital. Methods: Restrospective study analyzed all patients of brain – dead donor liver transplantation who performed  in VietDuc university hospital from 4/2012 to 4/2022. The following data were collected: Age, gender, medical past history, Child-Pugh and MELD score, indications, technique features, postoperative complications, 30-day mortality rate, overall survival  rate (OS). Results: 72 patients were included. The mean age was 51,3 ± 11,2, male/ femal ratio 68/4 (94,4%/5,6%), HBV infection of 80,6%. The mean MELD score was 14,7 ± 9.3; the rate of Child-Pugh A, B and C were 50%, 19,4%, 30,6%. Hepatocellular carcinoma, liver cirrhosis and acute liver failure or acute on chronic liver disease account for 62,5%, 25% and 12,5% respectively in liver transplantation indications. Hepatic venous outflow reconstruction consisted of classic technique 4,2%, piggyback technique 95,8%. Early surgical complications following liver transplantation consist of bleeding 5,6%, bile leakage 1,4 %, portal vein thrombosis 2,8%, hepatic artery thrombosis 1,4%. Medical complications consist of acute rejection 4,2%, CMV infection 0%. 30-day mortality was 4,2%. 1, 3 and 5-year OS were 84,7%%, 81,7% and 77,4% respectively. Conclusion: Brain – dead donor liver transplantation is an effective and safe therapy for end stage liver diseases and hepatocellular carcinoma, help to lengthen the survival of the post-transplanted patients.