NHẬN XÉT KẾT QUẢ ĐO NỒNG ĐỘ NITRIC OXIDE TRONG KHÍ THỞ RA Ở NGƯỜI BỆNH CÓ CHỒNG LẤP HEN VÀ BỆNH PHỔI TẮC NGHẼN MẠN TÍNH GIAI ĐOẠN ỔN ĐỊNH

Abstract

Objectives: To evaluate the results of measuring fraction of exhaled nitric oxide in patients with stable asthma - chronic obstructive pulmonary desease overlap receiving outpatient treatment at the Pulmonary disease management Clinic - Bach Mai Hospital. Methods: A cross-sectional descriptive study was carried out on 50 patients with a confirmed diagnosis of ACO according to Consensus GesEPOC-GEMA (Spanish COPD Asthma Management guidelines) who were treated as outpatients at the Pulmonary disease management Clinic - Bach Mai Hospital from September 2021 to September 2022. Results: Research on 50 ACO patients with a mean age of 66,5 ± 9,4 years old; all patients are male and 100% of the patients smoked. History of asthma (44%), allergic rhinitis (26%), 20% of patients have both asthma and allergic rhinitis; 10% with other allergies. The mean FeNO level is 20,88 ± 11,98 ppb. The FeNO levels in the group of patients with a history of asthma, a history of allergic rhinitis, and a history of ICS use were all greater than the group without a history, there was no statistically significant difference with p >0.05. There was no correlation between FeNO with age, cigarette smoking, mMRC dyspnea scale, Spirometry or the history of the exacerbation. The result shows that FeNO doesn’t have a correlation with the number of eosinophils. However, the FeNO levels with a history of asthma has a positive correlation with the number of eosinophils with correlation coefficient r =0,344, the difference was not statistically significant with p >0.05.  Conclusion: FeNO in ACO patients with a history of asthma and allergic rhinitis is higher than in patients without a history of asthma or allergic rhinitis. There was no correlation between FeNO and the number of eosinophils in peripheral blood, however the FeNO levels in ACO patients with a history of asthma has a positive correlation with the number of eosinophils in peripheral blood.