ĐÁNH GIÁ TÍNH NHẠY CẢM KHÁNG SINH CỦA VI KHUẨN GÂY NHIỄM TRÙNG ĐƯỜNG MẬT DO SỎI ĐIỀU TRỊ TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI

Abstract

Retrospective descriptive study on patients diagnosed with biliary tract infection due to stones according to the Tokyo 18 guidelines and treated with percutaneous transhepatic biliary drainage at Hanoi Medical University Hospital from 2020 to 2024, to identify the causes of infection and the antibiotic sensitivity of isolated bacteria. Results: Of 102 patients, the rate of biliary tract infection grade I, II, III were 40,2%; 37,3%; 22.7%, respectively. Bile culture was positive in 78,4% of cases, of which 66,7% were isolated a single pathogen and 11,7% with two or more pathogens. The most common bacteria were E. coli, Enterococcus spp., P. aeruginosa, and Klebsiella spp. Notably, 67,3% of isolated bacteria were ESBL producers, with ESBL-producing E. coli accounting for 78,8%. E. coli was susceptible to amikacin 97%, imipenem-cilastatin 88,2%, ertapenem 90%, meropenem 82,4%, cefotaxime 61,8%, cefepime 43,8%. Most strains of Enterococcus spp. were sensitive to piperacillin-tazobactam, vancomycin, and linezolid. Conclusion: Gram-negative bacteria were the predominant pathogens of the biliary tract infections. Isolated E. coli strains have reduced sensitivity to 3rd and 4th generation cephalosporin, quinolone group. Therefore, it is necessary to assess the antibiotic susceptibility of pathogenic bacteria every year for developing antibiotic guideline.