HISTOPATHOLOGICAL CHARACTERISTICS OF ALCOHOLIC LIVER DISEASE
Main Article Content
Abstract
Objective: To determine the histopathological characteristics of alcoholic liver disease. Subjects and methods: 60 patients with alcoholic liver disease were inpatient at 103 Military Hospital, from January 2015 to July 2017. The research indicators are fatty liver morphology and liver fibrosis stage according to Metavir, including: F0 (no fibrosis), F1 (mild fibrosis); F2 (moderate fibrosis), F3 (severe fibrosis) and F4 (cirrhosis). Results and conclusion: 100% of patients with alcoholic liver disease had fatty liver. The majority were fatty dropsy (71.7%), mild (93.3%), and in zone 1 (90.0%). Some other common lesions are foamy degeneration (100%), Mallory body (65.0%), chromophore (28.3%) and hepatocellular eosinophilia (15.0%). Evaluation of liver fibrosis stage according to Metavir classification showed no liver fibrosis (F0) was 6.7%; mild fibrosis (F1) was 50.0%; moderate liver fibrosis (F2) was 11.7%; Severe cirrhosis (F3) was 15.0% and cirrhosis (F4) was 16.7%.
Article Details
Keywords
Alcoholic liver disease, histopathology, liver fibrosis, liver cirrhosis
References
2. Lê Quốc Tuấn (2019), Nghiên cứu đặc điểm lâm sàng, cận lâm sàng và nồng độ một số cytokin huyết tương trên bệnh nhân mắc bệnh gan mạn do rượu, Luận án Tiến sĩ y học, Đại học YD Thái Nguyên.
3. Vũ Thị Thu Trang (2019), Nghiên cứu đặc điểm lâm sàng, một số xét nghiệm, siêu âm và mô bệnh học bệnh gan nhiễm mỡ, Luận án Tiến sĩ y học, Viện NCKHYDLS 108
4. Altamirano J., Miquel R., Katoonizadeh A. et al. (2014), “A histologic scoring system for prognosis of patients with alcoholic hepatitis”, Gastroenterology, 146: 1231–1239.
5. Celli R., Zhang X. (2014), “Pathology of Alcoholic Liver Disease”, Journal of Clinical and Translational Hepatology, vol. 2, 103–109.
6. Dubois M., Sciarra A., Trépo E. Et al. (2020), “Histologic parameter score does not predict short-term survival in severe alcoholic hepatitis”, United European Gastroenterol J., 8(9):1003-1012.
7. Ntandja Wandji L. C., Gnemmi V. et al. (2020), “Combined alcoholic and non-alcoholic steatohepatitis”, JHEP Rep., 2(3): 100- 101.
8. Sakhuja P. et al (2014), “Pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis? World J Gastroenterol., 20 (44): 16474-16479.