VI KHUẨN ĐA KHÁNG THUỐC TRÊN BỆNH NHÂN VIÊM PHỔI MẮC PHẢI CỘNG ĐỒNG Ở NGƯỜI LỚN TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ

Abstract

Background: Multidrug-resistant organisms (MDROs) have led to a significant increase in antibiotic resistance and pose a major challenge in empirical antibiotic selection for the treatment of community-acquired pneumonia (CAP) in adults, with the research objective: To determine the prevalence of community-acquired pneumonia (CAP) caused by MDROs. Through the antibiotic resistance rates of major pathogens, propose initial antibiotic use. Subjects and methods: A descriptive cross-sectional study was conducted on 148 adult CAP patients requiring hospitalization at the Department of Respiratory Medicine, Can Tho Central General Hospital. Results: The prevalence of MDRO infection was 89.2%, predominantly MDR Acinetobacter baumannii and MDR Klebsiella pneumoniae, with rates of 45.5% and 33.3%, respectively. Although the predominant pathogens exhibited high levels of resistance to Carbapenems, β-lactams, and Fluoroquinolones, ceftazidime/avibactam, amikacin, gentamicin, minocycline, and colistin demonstrated low resistance rates. Conclusion: Ceftazidime/avibactam, amikacin, gentamicin, minocycline, and colistin should be prioritized for initial use in CAP patients.