ĐÁNH GIÁ ĐẶC ĐIỂM LÂM SÀNG VÀ HIỆU QUẢ ĐIỀU TRỊ BỆNH LẬU CẤP BẰNG CEFTRIAXONE 250MG TIÊM BẮP VÀ CEFIXIME 400MG UỐNG LIỀU DUY NHẤT

Abstract

This study was conducted with two objectives: (1) To investigate the clinical characteristics and associated factors of uncomplicated gonorrhea, and (2) To compare the treatment efficacy of intramuscular ceftriaxone 250mg and oral cefixime 400mg single-dose regimens. The study was carried out from January 2024 to August 2024 at the National Dermatology and Venereology Hospital, with 150 patients enrolled, of whom 79 were randomly assigned to two treatment groups. After 7 days, the clinical cure rate was 87.2% (34/39) in the cefixime group and 92.5% (37/40) in the ceftriaxone group, with no statistically significant difference (p = 0.481). The bacterial clearance rate was 92.3% for cefixime and 97.5% for ceftriaxone (p = 0.358). In terms of adverse events, diarrhea was reported more frequently in the cefixime group (7.7%) compared to the ceftriaxone group (5%), and no allergic reactions were observed in either group. The results suggest that both antibiotics are effective and safe in the treatment of uncomplicated gonorrhea, with ceftriaxone showing a slightly higher efficacy, though the difference was not statistically significant.