ẢNH HƯỞNG CỦA PHÂN LOẠI PHÂN TỬ ĐẾN THỜI GIAN SỐNG THÊM TRONG UNG THƯ BIỂU MÔ TUYẾN VÚ XÂM NHẬP

Abstract

Objective: determine the free-disease (DFS) and overall (OS) observed five-year survival rate of female breast cancer patients, as well as investigate the affecting of molecular subtypes to survival. Patients and method: Retrospective data from Bach Mai and Ha Noi cancer hospitals comprised 300 women who were diagnosed with breast cancer between January 1st, 2017, and June 31st, 2019, and were followed up to June 31st, 2024 (cut off point for follow-up). To evaluate survival, Kaplan-Meier analysis was conducted. Using the log rank test and Cox regression analysis, the factors influencing the survival rate and recurrence were examined. Results: The OS and DFS rates were 91.3% and 93%, respectively. The distribution by molecular subtypes as follows LumA, LumB/Her2-, LumB/Her2+, Her2, bộ ba âm tính, the OS rates were 97.1%, 93.3%, 90%, 83.3% và 85%, respectively; the DFS rates were 95.1%, 86.7%, 94%, 93.8% và 95%, respectively. There were statistically significant associations between molecular subtypes and OS (p = 0.029) but they were independent of DFS (p = 0.308). Conclusion: Molecular subtypes were useful in predicting the prognosis of breast cancer patients.